Lecture 8 Pharmacodynamics Drug Dosing Safety and Efficacy

Discussion of relationships between a dose of a drug and it's response, captured by the dose-response curve. Description of the potency, affinity and efficacy of drugs, their therapeutic range, effective doses and lethal doses. Discussion of drug interactions, problems with polypharmacy as well as placebo and nocebo effects including discussion of exaggerated placebo effects in antidepressant research.