Drug Response Curve (DRC) of Acetylcholine

The dose–response relationship describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (Acetylcholine) after a certain exposure time. Studying dose response, and developing dose–response models, is central to determining "safe" and "hazardous" levels and dosages for drugs, potential pollutants, and other substances to which humans or other organisms are exposed. These conclusions are often the basis for public policy.Dose–response relationships generally depend on the exposure time and exposure route (e.g., inhalation, dietary intake); quantifying the response after a different exposure time or for a different route leads to a different relationship and possibly different conclusions on the effects of the stressor under consideration. This limitation is caused by the complexity of biological systems and the often unknown biological processes operating between the external exposure and the adverse cellular or tissue response A dose–response curve is a simple X–Y graph relating the magnitude of a stressor (e.g. concentration of a pollutant, amount of a drug, temperature, intensity of radiation) to the response of the receptor (e.g. organism under study). The response may be a physiological or biochemical response, or even death (mortality), and thus can be counts (or proportion, e.g., mortality rate), ordered descriptive categories (e.g., severity of a lesion), or continuous measurements (e.g., blood pressure). A number of effects (or endpoints) can be studied, often at different organizational levels (e.g., population, whole animal, tissue, cell). The measured dose (usually in milligrams, micrograms, or grams per kilogram of body-weight for oral exposures or milligrams per cubic meter of ambient air for inhalation exposures) is generally plotted on the X axis and the response is plotted on the Y axis. ............................................................................................................................................................................................................................................... Other Important Information is there in this video If you like this video, Don't Forgot to like and share video. any queries and questions you can comment If you want ppt, you can contact me on the following mail Email - [email protected] Subscribe my channel - https://www.youtube.com/channel/UCn60cZol_8XLvVkwanExIfw Thank You For Watching.