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The exact cause of comedo naevus is unknown, but it is thought to be due to cutaneous mosaicism; that is, a line of cells with a genetic error. If this error occurs early in the development of the embryo, the cells may spread out to cause multiple comedo naevi.
Mutations in FGFR2 have been detected in the naevi of some patients. FGFR2 is the same gene that has found to be abnormal in a more generalised severe genetic condition, Apert syndrome, so the comedo naevus may be a ‘mosaic’ of Apert syndrome (some cells have the abnormal gene, and other cells have the normal gene). Apert syndrome causes craniofacial dysostosis (abnormalities of the bone structure of the skull and face) and other skeletal abnormalities. Patients with Apert syndrome often suffer from severe acne, which also arises within a comedo naevus.
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