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Dr Marysia Tweet, a physician, and Dr Rajiv Gulati, a Consultant, both in the Division of Cardiovascular Diseases at Mayo Clinic in Rochester, MN, review their article appearing in the August 2015 issue of Mayo Clinic Proceedings, where they provide clinicians with updated information for diagnosing and treating the under-recognized condition of spontaneous CAD, which usually appears in younger women with symptoms mimicking heart attack and which requires radically divergent treatment options. Available at: http://tinyurl.com/ppj57kp