Cell Death in B

This work explores the reminiscences of a CD8+ T cell's life from its deathbed. Starting with development in the thymus, this composition will briefly survey the initial naivety, the activation through binding to an antigen-presenting cell, and the destruction of antigen-specific target cells as part of the immune response. The crux of the piece will emphasize the termination of the immune response due to the elimination of the pathogen, resulting in the intrinsic Bim-mediated apoptosis of the CD8+ T cell. In highlighting the finality of the cell's death from the declining immune response, the recording will both mourn and praise a fulfilled life. Music by Alecia Moore, Max Martin, and Johan Schuster Words and Arrangement by Austin Mudd Styled after Delilah of the Sing-Off Soloist: Brendan Jun All Other Parts: Austin Mudd Hey, slow it down Why is Bim active now Why is Bim active now Yeah, I'm afraid Why am I dying now Why am I dying now There used to be a time When I was simply immature I bound no antigen My life was such a bore Now look at me I obtained a mate From APC With a viral bait This infection Yeah, it's going to flee From the Fas and granzymes Hey, here comes a killer cell Here comes a killer cell Here comes a killer cell Yeah, fought the virus And the infected cells It was a long war But we, we prevailed Using caspase-3 We defeated the enemy Now that they're gone IL-2 has decreased No BCL-2 Is messing up me Mitochondria Need a second to breathe While they leak out their guts Hey, why am I dying now Bim's killing me While cytochrome c Leads to cleaving of My DNA I'm leaving this world 'Cause the infection's gone So I'll say my good byes Hey, why am I dying now Why is Bim active now Why am I dying now Here comes a killer cell